Functional Genomics Unit (FGU) Microarray Data Site

The Functional Genomics Unit (FGU)

The FGU was established on August 2000 with the aim of implementing genomic information and post-genomic technologies to the study of human diseases. The FGU is directed by Dr Naftali Kaminski. Currently the research at the FGU is mainly focused on studying large scale gene patterns using Affymetrix microarrays. We are evaluating also alternative methods for custom made arrays. The FGU aims to become a leader in medical genomics and a center for collaboration between academia and the bio-tech industry. An integral part of the work at the FGU is implementing established bioinformatic approaches to analysis of gene expression data as well as developing (through collaborations) of new approaches to analysis. In the last year we have actively engaged in multiple collaborative projects in order to encourage scientists to learn microarray technology and to help members of the community to obtain preliminary data using microarrays.

Main research projects (in brackets, last names of team leaders):

The basic molecular mechanisms of of interstitial lung diseases. (Kaminski, Friedman, Yakhini, Ben-Dor, Selman).

LUCA - Lung cancer analysis and classification project (Kaminski, Friedman N, Franklin, Yakhini, Ben-Dor, Rechavi, Krupsky, Perleman, Godring-Aviram, Friedman E)

Analysis of gene expression patterns of the response to exercise (Ben-Dov, Kaminski)

Analysis of gene networks that underlie the response of airway resident cells to cytokines relevant to asthma and airway remodeling (Kaminski, Lee, Sheppard, Friedman)

Genetic networks that underlie pediatric hematologic malignancies (Rechavi, Israeli)

Bioinformatic and computational approaches to analysis of gene expression data (Kaminski, Friedman, Yakhini, Ben-Dor)

Molecular characteristics of Multiple Sclerosis (Achiron, Mandel, Kaminski, Friedman)

Large Collaborative Projects

Mechanisms of DNA damage (Shiloh, Shamir, Rechavi, Kaminski, MOST Interdisciplinary grant))

Toxicity prediction, Pharama-logica consortium (Kaminski and members of the consortium)

Several Projects that address the Mechanisms of Pulmonary Fibrosis (Kaminski and collaborators from University College of London, Free University of Mexico City, UCSF  and University of Michigan)

Personnel (see members)

Director - Dr. Naftali Kaminski 

Phone: 972-3-5305772

Fax: 972-3-5302147

E-mail: kamins@sheba.health.gov.il

Lab project manager – Dr Iris Shahar 

Phone: 972-3-5302147

Fax: 972-3-5302147

E-mail: I_shahar@ sheba.health.gov.il

Technicians: 4 technicians are currently employed.

Students: 2PhD students and 2 MsC students.

Equipment and space

The microarray lab at the functional genomics unit has currently a space of 96sqm. The lab is fully equipped for microarray experiments including: A complete Affymetrix system – Hybridization oven, fluidics machine and a scanner. PCR machine. Dedicated RNA and DNA work spaces and tools, including multiple pipette sets, dedicated benches and a protected PCR/UV station. Centrifuges, benchtops, cooled and regular, SpeedVac, Biophotometer, multiple dry heating blocks. Power supplies and gel running aparati. 4^oc, -20 ^oc, and  -80 ^oc refrigerators and freezers.  Fume and cell culture hoods

3 dedicated high end PIII analysis workstations, 

2 Affymetrix analysis workstations.

Software: Genechip 5.0, D-chip, Treeview, Cluster, GeneCluster, GeneData curator, Scoregene Package, Biotools , GenMapp

The site is still under construction and we apologize for any broken links and inconveniences. To cite the data please reference the relevant paper.
For problems or questions regarding this web contact fgu@sheba.health.gov.il.
Last updated: 22/04/02.

This site is hosted by the Computational Molecular  Biology Lab, Hebrew University