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Functional Genomics Unit (FGU) Microarray Data Site

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Figure 3. MMP7-/- mice are protected against bleomycin-induced pulmonary fibrosis. Increase in lung hydroxyproline content in lungs of wild type (MMP-7+/+) mice 14 days after bleomycin injection is significantly higher than in MMP-7-/- mice on both C57BL6 and 129SvJ background. Increase values were calculated by subtracting mean hydroxyproline content (mg hydroxyproline/lung) of lungs of saline injected animals from the hydroxyproline content of lungs 14 days after bleomycin (A). Comparison of semi quantitative morphometric analysis of lung histology 14 days after bleomycin (B) and representative histology of MMP-7+/+ (C) and MMP-7-/- mice (D). Data (means ± SEM) are representative of at least two comparable experiments with 6 mice per group; * P < 0.01 relative to bleomycin treated MMP+/+ mice.

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Last updated: 23/04/02.
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